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Isi Uzo (also Isi-Uzo) is a Local Government Area (LGA) of Enugu State, Nigeria bordering Benue State and Ebonyi State. The largest city within Isi Uzo is Eha-Amufu, and the region is host to 23 autonomous communities with its capital in Ikem and the oldest town is Umualor (Umuero). After independence, the local government area was created in 1976. Isi-Uzo is a constituent of the Enugu East Senatorial District and has a population of approximately 220,000.
Isi Uzo has an area of 877 square kilometers and a population of 148,415 (from the 2006 census), however modern estimates set the population at around 220,000. The LGA is a primarily rural region that relies heavily on local agribusiness initiatives for economic growth. The government area has over sixty local markets used for commerce, and the area's postal code is 412.
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